What is MIMRYLO™ (rusfertide) and how does it work?
With erythrocytosis in PV, your body produces too many red blood cells
As a person with polycythemia vera (PV), you may know that your body produces too many red blood cells, but you may not know how or why. Think of your body’s process for making red blood cells like an assembly line in a factory. A key raw material is the mineral iron. Normally, hepcidin (the body’s natural iron manager) helps make sure the right amount of iron is released. In people with PV, the body's bone marrow does not allow the iron manager (hepcidin) to control the iron levels. Because of this, your body produces too many red blood cells.
Step 1: In people with PV, it’s like there aren’t enough managers (hepcidin) for the job, so the iron supply isn’t controlled the way it should be…
Step 2: ...and extra iron is sent to the bone marrow, where red blood cells are made. This fuels excess red blood cell production.
Step 3: Overproduction of red blood cells can make blood thicker, and affect how blood flows through the body.
Step 2: ...and extra iron is sent to the bone marrow, where red blood cells are made. This fuels excess red blood cell production.
Step 3: Overproduction of red blood cells can make blood thicker, and affect how blood flows through the body.
MIMRYLO works with your body to control red blood cell production by managing iron
Step 1: This is where MIMRYLO comes in. MIMRYLO is a therapy that acts like the body’s natural iron manager, hepcidin.
Step 2: MIMRYLO helps by limiting how much iron moves down the line to the bone marrow, where red blood cells are made.
Step 3: Less iron in the bone marrow helps to balance red blood cell production, so blood can flow more easily through the body.
Step 2: MIMRYLO helps by limiting how much iron moves down the line to the bone marrow, where red blood cells are made.
Step 3: Less iron in the bone marrow helps to balance red blood cell production, so blood can flow more easily through the body.